Wall Street is pointing toward losses Tuesday ahead of a two-day meeting of the Federal Reserve, which is facing the diametrically opposed challenges of potential inflation and a softening employment landscape.

Futures for the S&P 500 lost 0.7% and futures for the Dow Jones Industrial Average retreated 0.6%. Nasdaq futures slid 1%.

The Fed is expected to hold its benchmark interest rate steady for the third consecutive meeting after trimming them three times to close out 2024. Uncertainty over President Donald Trump’s trade policy — namely tariffs — has officials concerned about a potential resurgence of inflation, which has been hovering just above the Fed’s target rate of 2%.

The U.S. economy shrank 0.3% in the first quarter, the first drop in three years.

After enormous sell-offs with the market roiling from back-and-forth tariff announcements from the White House, Wall Street had been on a nine-day winning streak, its longest since 2004. That momentum lost steam Monday and the S&P 500 fell 0.6%.

This week’s pause coincides with a growing number of U.S. corporations pulling guidance do to uncertainty about what the tariffs will bring, and spelling out the economic hits they’ll take.

Shares of Ford Motor Co. fell 2.5% before the bell after the automaker said Monday it expects to take a $1.5 billion hit to its operating profit from tariffs this year. That followed General Motors, which last week trimmed its 2025 guidance and said it was anticipating a potential $5 billion tariff impact

Clorox sank 3.2% after it missed sales and profit targets in its most recent quarter and lowered its forecast to reflect “macroeconomic uncertainty” related to tariffs.

DoorDash tumbled more than 5% in premarket after the food delivery app said it was acquiring Britain’s Deliveroo for 2.9 billion pounds ($3.9 billion) in cash, expanding its business in Europe, Asia and the Middle East.

In reporting its most recent financial results, DoorDash said demand for deliveries remained strong in the first quarter, even as more Americans feel increasingly uneasy about the U.S. economy.

Elsewhere, markets in China advanced after reopening from “Golden Week” holidays.

When asked at a routine briefing about comments Trump’s comments on NBC that he won’t cancel tariffs on China to pave the way for trade talks, a Chinese Foreign Ministry spokesperson reiterated Beijing’s stance that the U.S. “should stop threatening and pressuring and engage in dialogue with China on the basis of equality, respect, and mutual benefit.”

“If they want to fight, we will fight to the end; if they want to talk, the door is open,” Lin Jian said.

Late last week, China’s Commerce Ministry said it was evaluating various U.S. missives about holding talks.

The Shanghai Composite index added 1% to 3,311.89, while the Hang Seng in Hong Kong was up 0.7% at 22,651.65.

A monthly survey measuring future activity in China’s services sector fell to its lowest level ever, excluding the pandemic, in a further sign the escalation of Trump’s trade war is hitting the world’s second-largest economy.

Meta CEO Mark Zuckerberg once considered separating Instagram from its parent company due to worries about antitrust litigation, according to an email shown Tuesday on the second day of an antitrust trial alleging Meta illegally monopolized the social media market.

In the 2018 email, Zuckerberg wrote that he was beginning to wonder if “spinning Instagram out” would be the only way to accomplish important goals, as big-tech companies grow. He also noted “there is a non-trivial chance” Meta could be forced to spin out Instagram and perhaps WhatsApp in five to 10 years anyway.

He wrote that while most companies resist breakups, “the corporate history is that most companies actually perform better after they’ve been split up.”

Asked Tuesday by attorney Daniel Matheson, who is leading the antitrust case for the Federal Trade Commission, which incidence in corporate history he had in mind, Zuckerberg responded: “I’m not sure what I had in mind then.”

Zuckerberg, who was the first witness, testified for more than seven hours over two days in the trial that could force Meta to break off Instagram and WhatsApp, startups the tech giant bought more than a decade ago that have since grown into social media powerhouses.

While questioning Zuckerberg on Tuesday morning, Matheson noted that he had referred to Instagram as being a “rapidly growing, threatening, network.” The attorney also pointed out Zuckerberg’s referring to trying to neutralize a competitor by buying the company.

But Zuckerberg said while Matheson was able to show documents in court that indicated his concern about Instagram’s growth, he also had many conversations about how excited his company was to acquire Instagram to make a better product.

Zuckerberg also said Facebook was in the process of building a camera app for sharing on mobile phones, and he thought Instagram was better at that, “so I wanted to buy them.”

Zuckerberg also pushed back against Matheson’s contention that the reason for buying the company was to neutralize a threat.

“I think that that mischaracterizes what the email was,” Zuckerberg said.

In his questioning of Zuckerberg, Matheson repeatedly brought up emails — many of them more than a decade old — written by Zuckerberg and his associates before and after the acquisition of Instagram.

While acknowledging the documents, Zuckerberg has often sought to downplay the contents, saying he wrote them in the early stages of considering the acquisition and that what he wrote at the time didn’t capture the full scope of his interest in the company.

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Social media platform X said Saturday it will close its operations in Brazil, claiming Brazilian Supreme Court Justice Alexandre de Moraes threatened to arrest its legal representative in Brazil if they did not comply with orders.

X is removing all remaining Brazil staff in the country “effective immediately,” though the company said service will still be available to the people of Brazil. The company did not clarify how it could claim to suspend operations while continuing to provide services to Brazilians.

Earlier this year, the company clashed with de Moraes over free speech, far-right accounts and misinformation on X. The company said his most recent orders amounted to censorship, and shared a copy of the document on X.

The Supreme Court’s press office didn’t immediately respond to Associated Press email requests seeking comment, or to confirm the veracity of the document, on Saturday.

In the United States, free speech is a constitutional right that’s much more permissive than in many countries, including Brazil, where de Moraes in April ordered an investigation into CEO Elon Musk over the dissemination of defamatory fake news and another probe over possible obstruction, incitement and criminal organization.

Brazil’s political right has long characterized de Moraes as overstepping his bounds to clamp down on free speech and engage in political persecution.

Whether investigating former President Jair Bolsonaro, banishing his far-right allies from social media, or ordering the arrest of supporters who stormed government buildings on Jan. 8, 2023, de Moraes has aggressively pursued those he views as undermining Brazil’s young democracy.

“Moraes has chosen to threaten our staff in Brazil rather than respect the law or due process,” the company said in a statement on X.

In a tweet Saturday morning, the self-proclaimed “free speech absolutist” and owner of X, Musk, said de Moraes “is an utter disgrace to justice.”

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Two higher-end models of the Apple Watch can go on sale again after a federal court temporarily lifted a sales halt ordered by the International Trade Commission over a patent dispute.

The ITC, a federal agency, ordered the halt in October to block Apple from using specific technologies underpinning a blood-oxygen measurement system in its Series 9 and Ultra 2 watches. Apple has been embroiled in an intellectual property dispute with the medical technology company Masimo over those technologies.

Apple cut off online sales of the watches in the U.S. last week just days from the Christmas holiday to comply with the ITC ruling. The court’s action will allow sales of the two Apple Watch models pending its decision on whether to also permit sales as it weighs Apple’s appeal.

The two watch models will be available at Apple’s online store by noon Pacific Time on Thursday, according to the company. They will return to some Apple stores Wednesday, with wider availability expected by Saturday.

This isn’t the first patent roadblock the Apple Watch has run into as the company morphs its watches into health-management devices. Last year, the ITC ruled that Apple had infringed on the wearable EKG technology of AliveCor — a decision the Biden administration declined to overturn. That dispute hasn’t directly affected Apple Watch sales yet because another regulatory body had ruled that AliveCor’s technology isn’t patentable. The legal tussle on that issue is still ongoing.

The patent headaches facing Apple as it tries to infuse more medical technology into its watch models make it increasingly likely the company will either have to start working out licensing deals or simply acquiring startups specializing in the field, Wedbush Securities analyst Dan Ives predicted.

In a historic ruling, Panama’s Supreme Court this week declared that legislation granting a Canadian copper mine a 20-year concession was unconstitutional, a decision celebrated by thousands of Panamanians activists who had argued the project would damage a forested coastal area and threaten water supplies.

The mine, which will now close, has been an important economic engine for the country. But it also triggered massive protests that paralyzed the Central American nation for over a month, mobilizing a broad swath of Panamanian society, including Indigenous communities, who said the mine was destroying key ecosystems they depend on.

In the unanimous decision Tuesday, the high court highlighted those environmental and human rights concerns, and ruled the contract violated 25 articles of Panama’s constitution. Those include the right to live in a pollution-free environment, the obligation of the state to protect the health of minors and its commitment to promote the economic and political engagement of Indigenous and rural communities.

The ruling would lead to the closure of Minera Panama, the local subsidiary of Canada’s First Quantum Minerals and the largest open-pit copper mine in Central America, according to jurists and environmental activists.

The court said the government should no longer recognize the existence of the mine’s concession and Panama’s President Laurentino Cortizo said “the transition process for an orderly and safe closure of the mine will begin.”

Analysts say it appears highly unlikely that Panama’s government and the mining company will pursue a new agreement based on the resounding rejection by Panamanians.

“There are sectors in the country that would like a new contract, but the population itself does not want more open-pit mining, the message was clear,” said Rolando Gordón, dean of the economics faculty at the state-run University of Panama. “What remains now is to reach an agreement to close the mine.”

Analysts say the mining company is free to pursue international arbitration to seek compensation for the closure based on commercial treaties signed between Panama and Canada. Before the ruling, the company said it had the right to take steps to protect its investment.

With the ruling, the Panamanian government and the mining company are headed for arbitration at the World Bank’s international center for arbitration of investment disputes, in Washington, said Rodrigo Noriega, a Panamanian jurist.

Marta Cornejo, one of the plaintiffs, said “we are not afraid of any arbitration claim” and that they are “capable of proving that the corrupt tried to sell our nation and that a transnational company went ahead, knowing that it violated all constitutional norms.”

In a statement after the verdict, the mining company said it had “operated consistently with transparency and strict adherence to Panamanian legislation.” It emphasized that the contract was the result of “a long and transparent negotiation process, with the objective of promoting mutual economic benefits, guaranteeing the protection of the environment.”

Cortizo, who had defended the contract arguing it would keep 9,387 direct jobs, more than what the mine reports, said that the closing of the mine must take place in a “responsible and participative” manner due to the impact it would have.

The company has said the mine generates 40,000 jobs, including 7,000 direct jobs, and that it contributes the equivalent of 5% of Panama’s GDP.

The court verdict and the eventual closure of the mine prompted more protests, this time by mine workers.

Google on Monday confronted the second major U.S. antitrust trial in two months to cast the internet powerhouse as a brazen bully that uses its immense wealth and people’s dependence on one of its main products to stifle competition at consumers’ expense.

The trial that opened in a San Francisco federal court targets the Google Play Store that distributes apps for the company’s Android software that powers virtually all the world’s smartphones that aren’t made by Apple.

The case, stemming from a lawsuit filed by video game maker Epic Games, alleges Google has created an illegal monopoly on Android apps primarily so it can boost its profits through commissions ranging from 15% to 30% on purchases made within an app.

“The result of what Google is doing is higher prices, lower quality and less choice for everybody,” Epic attorney Gary Bornstein said Monday during a 45-minute opening statement before the 10-person jury that will decide the case.

Google attorney Glenn Pomerantz attempted to debunk the portrait of the company having a stranglehold on Android apps by outlining a wide gamut of competition from rival mobile and video game console stores, as well as Apple’s store for apps that run on its iPhone software.

“Because Google faces strong competition from Apple and others, it cannot be and is not a monopolist,” Pomerantz asserted in his opening statement.

Google’s strategy to lean on Android’s competition with Apple and the iPhone in its trial with Epic is tinged irony. That’s because Google in September became immersed in the biggest U.S. antitrust trial in a quarter century — a case largely centered on payments that the company makes to Apple to ensure its dominant search engine automatically fields queries made on iPhones.

A federal judge on Friday will decide whether disgraced Theranos CEO Elizabeth Holmes should serve a lengthy prison sentence for duping investors and endangering patients while peddling a bogus blood-testing technology.

Holmes’ sentencing in the same San Jose, California, courtroom where she was convicted on four counts of investor fraud and conspiracy in January marks a climactic moment in a saga that has been dissected in an HBO documentary and an award-winning Hulu TV series about her meteoric rise and mortifying downfall.

U.S. District Judge Edward Davila will take center stage as he weighs the federal government’s recommendation to send Holmes, 38, to federal prison for 15 years. That’s slightly less than the maximum sentence of 20 years she could face, but far longer than her legal team’s attempt to limit her incarceration to no more than 18 months, preferably served in home confinement. Her lawyers have argued that Holmes deserves more lenient treatment as a well-meaning entrepreneur who is now a devoted mother with another child on the way.

Prosecutors also want Holmes to pay $804 million in restitution. The amount covers most of the nearly $1 billion that Holmes raised from a list of sophisticated investors that included software magnate Larry Ellison, media mogul Rupert Murdoch, and the Walton family behind Walmart.

While wooing investors, Holmes leveraged a high-powered Theranos board that included former U.S. Defense Secretary James Mattis, who testified against her during her trial, and two former U.S. Secretaries of State, Henry Kissinger and the late George Shultz, whose son submitted a statement blasting Holmes for concocting a scheme that played Shultz “for the fool.”

Davila’s judgment – and Holmes’ reporting date for a potential stint in prison -- could be affected by the former entrepreneur’s second pregnancy in two years. After giving birth to a son shortly before her trial started last year, Holmes became pregnant at some point while free on bail this year.

Federal prosecutors have asked a judge to sentence disgraced Theranos CE0 Elizabeth Holmes to 15 years in prison, arguing she deserves a lengthy prison term because her massive scheme duped investors out of hundreds of millions of dollars by falsely convincing them her company had developed a revolutionary blood testing device.

Calling the case “one of the most substantial white collar offenses Silicon Valley or any other District has seen,” prosecutors vehemently rejected defense attorneys’ characterization that Holmes had been unfairly victimized, in part by media coverage.

Holmes is set to appear for sentencing on Nov. 18 in federal court in San Jose, California, nearly a year after she was convicted of three felony counts of wire fraud and one felony count of conspiracy to commit fraud. She faces up to 20 years in prison for each count.

“She repeatedly chose lies, hype and the prospect of billions of dollars over patient safety and fair dealing with investors,” Assistant U.S. Attorney Robert S. Leach wrote in a 46-page brief filed Friday. “Elizabeth Holmes’ crimes were not failing, they were lying — lying in the most serious context, where everyone needed her to tell the truth.”

Holmes’ attorneys filed an 82-page document late Thursday calling for a lenient sentence of no more than 18 months, saying her reputation was permanently destroyed, turning her into a “caricature to be mocked and vilified.”

Besides asking that Holmes receive a lengthy prison sentence, prosecutors called for the 38-year-old pay $803,840,309 in restitution for her role in the yearslong scheme that turned her into one of the most widely respected and immensely wealthy entrepreneurs in the Silicon Valley and the United States.

“She preyed on hopes of her investors that a young, dynamic entrepreneur had changed healthcare. She leveraged the credibility of her illustrious board,” Leach wrote. “And, through her deceit, she attained spectacular fame, adoration, and billions of dollars of wealth.”

Leach also pointed to how, after Wall Street Journal reporter John Carreyrou exposed the scheme, Holmes “attacked him, along with his sources” and desperately tried to pin the blame on others.

“At trial, she blamed her COO (and longtime boyfriend), her board, her scientists, her business partners, her investors, her marketing firm, her attorneys, the media — everyone, that is, but herself,” Leach wrote.

The company’s former chief operating officer, 57-year-old Ramesh “Sunny” Balwani, was convicted on 12 felony counts of investor and patient fraud in July during separate trial. He is scheduled to be sentenced Dec. 7.

And Leach wrote that the health of actual patients was put into jeopardy by what Holmes had done.

“As money was drying up, she went to market with an unproven and unreliable medical device,” he wrote. “When her lead assay developer quit as Theranos launched, she chillingly told the scientist: ‘she has a promise to deliver to the customer, she doesn’t have much of a choice but to go ahead with the launch.’”

Holmes’ attorneys have argued that if U.S. District Judge Edward Davila does decide to send her to prison, she deserves a lenient sentence because she poses no danger to the public and has no prior criminal history.

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A judge ruled on Friday that Facebook owner Meta repeatedly and intentionally violated Washington campaign-finance law, and must pay penalties, the Washington state Attorney General’s Office said.

Attorney General Bob Ferguson’s office said the penalties will be determined at a later date and that the court also denied Meta’s effort to invalidate Washington’s law on political ad transparency.

The oral ruling happened during a hearing before King County Superior Court Judge Douglass North, The Seattle Times reported.

In a statement, Ferguson said his office defeated Facebook’s “cynical attempt” to gut Washington’s campaign-finance transparency law.

“On behalf of the people of Washington, I challenge Facebook to accept this decision and do something very simple – follow the law,” Ferguson said.

California-based Meta did not immediately respond to a request for comment from the newspaper.

The social media giant, which also owns Instagram and other social media platforms, has repeatedly objected to the requirements, and argued in a summary judgment motion that Washington’s law “unduly burdens political speech” and is “virtually impossible to comply with.”

The law allows financial penalties of $10,000 per violation, which can be tripled when violations are deemed intentional. The Attorney General’s Office asserts Facebook has committed hundreds of violations since 2018.